pka in 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39217	PKA-IN-1		PKA
	PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study diseases of the immune system.		PKA
T72885	Akt1&PKA-IN-1
	Akt1&PKA-IN-1 is a potent dual inhibitor targeting Akt and PKA, exhibiting IC50 values of 0.11 μM for Akt, 0.03 μM for PKAα, and 9.8 μM for CDK2. Notably, it demonstrates selectivity for cyclin-dependent kinase 2 (CDK2).
T5S2178	Fargesin	(+/-)-Fargesin	Adrenergic Receptor
	1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating...		Adrenergic Receptor
T4444	A-674563 HCl (552325-73-2(free base))		ERK , Akt , PKA , CDK , PKC
	A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for A...		ERK , Akt , PKA , CDK , PKC
T4973	Paraxanthine	1,7-DIMETHYLXANTHINE	Endogenous Metabolite
	Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc...		Endogenous Metabolite
T8969	API-1	NSC177223	Akt
	API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .		Akt
T6S1684	8-Gingerol		Antioxidant , Antibacterial , TRP/TRPV Channel
	1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic...		Antioxidant , Antibacterial , TRP/TRPV Channel
T6S1740	Nardosinone		Others
	1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...		Others
T3211	Midostaurin	N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251	Others , PKC
	PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel...		Others , PKC
T76381	H1-7 (histone H1 phosphorylation site), PKA Substrate
	H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].
T73247	PIM1-IN-4		Pim
	PIM1-IN-4 (Compound 8) is a potent PIM1 inhibitor with significant inhibitory activity against five additional enzymes: SGK-1, PKA, CaMK-1, GSK3β, and MSK1, rendering it a potentially useful agent for cancer research [1]...		Pim
T28695	SB-747651A	SB 747651A
	SB-747651A is a potent, ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1, IC50 = 11 nM). It targets the N-terminal kinase domain. SB-747651A inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity...
T76481	PKI (14-24)amide
	PKI (14-24)amide is a potent inhibitor of Protein Kinase A (PKA), demonstrating strong inhibition of cyclic AMP-dependent protein kinase activity in cell homogenates [1] [2].
T74195	4′-Demethylnobiletin
	4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment linked to NMDA receptor antagonism th...
T75739	PKI(5-24) TFA
	PKI(5-24) TFA is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), characterized by its potent and competitive inhibition properties, exhibiting a K i of 2.3 nM. It corresponds to residues 5-24 found ...
T83684	Myelin Basic Protein Peptide (mouse, bovine) TFA	Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide
	Myelin basic protein (MBP) peptide, a selective substrate for protein kinase C (PKC) over protein kinase A (PKA), casein kinase 1 (CK1), CK2, phosphorylase kinase, and calcium/calmodulin-dependent protein kinase (CaMKII)...
T75989	Malantide TFA
	Malantide TFA, a synthetic dodecapeptide, originates from the phosphorylation site targeted by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Exhibiting a high specificity for PKA with a Mi...
T78066	BBT		Calcium Channel
	BBT enhances glucose-stimulated insulin secretion (GSIS) in compromised conditions, demonstrates anti-hyperglycemia effects, and shields β-cells from cytokine- or streptozotocin (STZ)-triggered apoptosis in type 2 diabet...		Calcium Channel
T36679	Rp-cAMPS sodium salt
	Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b...
T83683	St-Ht31 ammonium	sHt31
	st-Ht31, a cell-permeable stearated peptide derived from the amphipathic helix domain of A-kinase anchoring proteins (AKAPs), effectively binds protein kinase A (PKA), impacting PKA's cellular interactions without alteri...